This is the third in the series of annual scientific symposia hosted by the Australian Society for Molecular Imaging. It brings together researchers from a wide range of disciplines interested in the development and applications of multi-modality molecular imaging. This year’s theme is “Detectors and Signal Processing for Multi-modality Imaging”. Other topics covered include novel molecular imaging probes and applications of molecular imaging in neuroscience, cardiology, metabolic disorders and cancer, to name a few.